Synthesis of folic acid functionalized gold nanoclusters for targeting folate receptor-positive cells
نویسندگان
چکیده
منابع مشابه
Synthesis of functionalized fluorescent gold nanoclusters for acid phosphatase sensing.
A novel and convenient one-pot but two-step synthesis of fluorescent gold nanoclusters, incorporating glutathione (GSH) and 11-mercaptoundecanoic acid (MUA) as the functionalized ligands (i.e. AuNCs@GSH/MUA), is demonstrated. Herein, the mixing of HAuCl4 and GSH in aqueous solution results in the immediate formation of non-fluorescent GSH-Au(+) complexes, and then a class of ∼2.6 nm GSH-coated ...
متن کاملFolate-Conjugated Gold Nanoparticles (Synthesis, Characterization and Design for Cancer Cells Nanotechnology-based Targeting)
A new folate-conjugated gold nanoparticle (AuNP) has been designed to selectively target the folate receptor that is overexpressed on the surface of tumoral cells. For this purpose, we made 4-aminothiophenol, as a bifunctional linker to react with HAuCl4 in the presence of sodium borohydride and it was binded to the AuNP surface through its thiol group. Then, we conjugated amino-terminated nano...
متن کاملfolate-conjugated gold nanoparticles (synthesis, characterization and design for cancer cells nanotechnology-based targeting)
a new folate-conjugated gold nanoparticle (aunp) has been designed to selectively target the folate receptor that is overexpressed on the surface of tumoral cells. for this purpose, we made 4-aminothiophenol, as a bifunctional linker to react with haucl4 in the presence of sodium borohydride and it was binded to the aunp surface through its thiol group. then, we conjugated amino-terminated nano...
متن کاملFolate Receptor-Targeting Gold Nanoclusters as Fluorescence Enzyme Mimetic Nanoprobes for Tumor Molecular Colocalization Diagnosis
Nanoprobes with enzyme-like properties attracted a growing interest in early screening and diagnosis of cancer. To achieve high accuracy and specificity of tumor detection, the design and preparation of enzyme mimetic nanoprobes with high enzyme activity, tumor targeting and excellent luminescence property is highly desirable. Herein, we described a novel kind of fluorescence enzyme mimetic nan...
متن کاملStraightforward and robust synthesis of monodisperse surface-functionalized gold nanoclusters
Gold nanoclusters are small (1-3 nm) nanoparticles with a high surface area that are useful for biomedical studies and drug delivery. The synthesis of small, surface-functionalized gold nanoclusters is greatly dependent on the reaction conditions. Here, we describe a straightforward, efficient and robust room temperature one-pot synthesis of 2 nm gold nanoclusters using thioglucose as a reducin...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nanotechnology
سال: 2019
ISSN: 0957-4484,1361-6528
DOI: 10.1088/1361-6528/ab437c